The objective of this Postdoctoral Fellowship is the development of an original Drug Delivery System. This system will be based on a polymeric material derived from a natural biomolecule known for its antioxidant and antiproliferative properties towards cancer cells. The drug targeted under this project is gallic acid, a natural polyphenolic acid easily accessible in large quantities in free form or in the form of gallotannins from numerous plants, oak bark or co-products of the first order transformation of oak wood. The gallic acid will be functionalized with a polymerizable group via a pH-sensitive spacer. The produced monomer will be polymerized, then the polymer will be formulated into nanoparticles. Thanks to the pH-sensitive spacer, this drug delivery system will lead to the gradual and controlled release of gallic acid and will make it possible to propose an effective anticancer treatment.
- PhD thesis offer : Highly-filled extruded materials: from formulation to final mechanical & thermal properties – Collaboration IMT Lille Douai – Tarkett (25/05/2020)
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