The research project will deal with the development of new water-soluble antibacterial polymers based on peptide units. In this context, peptide-bearing monomers will be synthesized by solid-phase peptide synthesis, polymerized by reversible addition-fragmentation chain transfer (RAFT) controlled radical polymerization, characterized and investigated regarding their physico-chemical properties. The effect of the concentration, ionic strength of the aqueous solution and the temperature will be studied. The study of the bactericide effect of these polymers will be conducted at the laboratoire de Biomatériaux et Bioingénierie (Strasbourg). These biomaterials functionalized with these new polymers should present a bactericide effect.

Publié le 16/12/2018