By approaching the size and the principles of structure and function of proteins, synthetic nanoparticles (NPs) could access new domains of functionalities. For example, the dynamic nature of protein activity could be integrated in NPs. The objective of this PhD thesis will be to open this way to polymeric nanoparticles by following a route between biomimetics and synthetic biology.
To obtain such NPs we will use nanoprecipitation of a library of specifically designed amphiphilic polymers. Studying the kinetics of particle formation will be used to control size, structure, and surface properties of the NPs by adjusting polymer chemistry and assembly conditions. Mimicking the surface properties of proteins will then allow to optimize the stability of the particles in biological media and use them to assemble 3D materials in situ upon application of stimuli (pH and electrochemical potential).
The PhD student will thus be able to learn a variety of techniques ranging from polymer chemistry, over NP assembly and characterization to the study of their behavior in biological systems.

Publié le 25/08/2019