In the frame of 3DEStim, we propose:

  • To develop 3D electroactive scaffolds for cell culture combining both electrical and mechanical stimulation. Such materials will be elaborated first from highly porous polyHIPE structures. A conducting polymer will be embedded into this matrix by oxidative chemical vapor phase polymerization of corresponding monomer.
  • To functionalize these scaffolds with adhesive ECM glycoproteins for displaying controlled properties and signal dynamic of in vivo cell environments. The cells responses to such ECM-containing scaffolds will be then studied.
  • To establish the proof of the concept of using such a device for drug response screening, firstly focusing on anticancer drug response, especially of ovarian cancer metastasis by tuning the scaffold to model their peritoneum implantation site, which displays in vivo dynamic resulting from breathing, digestion, and bodily movements.

Thereafter, capitalizing on the acquired know-how, the 3D electoactive scaffold features as well as its ECM functionalization will be adapted to varied cell types in regard with the desired drug assays.

Publié le 01/12/2019