Electrostatic complexes are good candidates for the development of particles that can be used as vectors of active ingredients due to their versatility. Many systems can indeed be obtained in terms of structure, sizes and properties. Nevertheless, their main limitation is related to their low colloidal stability according to physico-chemical conditions (pH in particular). A strategy studied in the literature consists of cross-linking the complex once it is formed, which is usually carried out by a chemical pathway. Another possible but still little reported crosslinking pathway to obtain a particle with increased stability is the enzymatic pathway.
The envisaged system consists of the enzymatic cross-linking of a particulate electrostatic complex (nano or micro) formed between two agro-based polysaccharides.
Polysaccharides are well known to form colloidal objects (including coacervates) by electrostatic interactions. A coacervate being stable only for a fairly short time (because of coalescence phenomena taking place), an enzymatic cross-linking step should increase the stability of the complexes.

Publié le 21/05/2022