G protein-coupled receptors (GPCRs) are the largest family of receptors and drug targets. GPCRs exhibit complex functional behaviors, as signaling is affected by extracellular ligands, cytoplasmic proteins, oligomerisation, and protein/lipid interactions, which require a membrane environment. Lipid-bilayer nanodiscs encapsulated by amphiphilic copolymers are promising nanoscale yet native-like membrane mimics. However, existing polymers suffer from high charge density and other limitations that alter the sensitive conformational landscapes of GPCRs.
Open Position for a Postdoctoral Researcher : New Polymer Belts for Lipid-Bilayer Nanodiscs to Study the Molecular Basis of GPCR Signalling – S2CB, Avignon University (22/01/2023)
par Frédéric PELASCINI | 22 Jan 2023 | Propositions de Post-Doctorat