G protein-coupled receptors (GPCRs) are the largest family of receptors and drug targets. GPCRs exhibit complex functional behaviors, as signaling is affected by extracellular ligands, cytoplasmic proteins, oligomerisation, and protein/lipid interactions, which require a membrane environment. Lipid-bilayer nanodiscs encapsulated by amphiphilic copolymers are promising nanoscale yet native-like membrane mimics. However, existing polymers suffer from high charge density and other limitations that alter the sensitive conformational landscapes of GPCRs.
- Offre de thèse : Production hydrogène à grande échelle : Développement de nouveaux matériaux polymères pour électrolyseur alcalin – LPPI, CY Cergy Paris Université (30/01/2023)
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