G protein-coupled receptors (GPCRs) are the largest family of receptors and drug targets. GPCRs exhibit complex functional behaviors, as signaling is affected by extracellular ligands, cytoplasmic proteins, oligomerisation, and protein/lipid interactions, which require a membrane environment. Lipid-bilayer nanodiscs encapsulated by amphiphilic copolymers are promising nanoscale yet native-like membrane mimics. However, existing polymers suffer from high charge density and other limitations that alter the sensitive conformational landscapes of GPCRs.

Publié le 22/01/2023